Life Sciences

Projects with a purpose

OTC drugs to regenerative medicine; ethical research to distribution supply chain;

Lorien has long been associated with the Life Sciences industry, in all of its forms, and at all scales of manufacture and research.

Our engineers support clients in the establishment of new facilities and the adaptation of existing facilities to meet new needs. In particular we offer solutions for;

  • Processing and formulation facilities
  • Filling, packaging and mechanical handling automation
  • GMP manufacturing suites
  • Discovery, microbiology and QC laboratories
  • Production laboratories
  • Procedure suites
  • Dispensary and blending suites
  • Cold rooms and other temperature controlled environments
  • General facility design: architectural, civil, structural and building services
  • Warehousing and distribution facilities
  • Utilities and plant rooms supporting GMP

Ethical pharmacological manufacture

Our project teams have direct application experience of ethical products manufacture:

  • Active Pharmaceutical Ingredient processing
  • Final dosage formulation: tablets, capsules, liquids, aerosols
  • Tablet coating
  • In-vitro diagnostics
  • Dispensary for batch formulation
  • Packaging operations
  • Finished goods supply chain

We take immense pride in developing projects that deliver – to our clients, and to patients.

Bill Treddenick, Director of Life Sciences

Studies to facility build; construction safety to production safety

Lorien project teams deliver Concept and Pre-Investment Studies, all the way through to detailed facility design and construction management.  We are our client’s project partners from the start to the end of the project cycle, and beyond. 

  • Site masterplans and concept design
  • Front-End Engineering Design
  • Tender design and planning consent / permitting
  • Scheme implementation, including construction planning, procurement and execution management
  • Construction safety management
  • GMP risk management - system impact assessment, project validation master plans, FMEA (to ISO60812)
  • Clinical risk management (such as ISO14971 Risk Control, and ISO13485 QMS for medical devices)
  • Production plant safety qualification, including CE Marking
  • Machine and area safety, including PUWER / AUWED and DSEAR / ATEX

Regenerative Medicine and Research Facilities

The Regenerative Medicines market is quickly becoming a significant part of the ‘Life Sciences’ sector.  Lorien has been involved in the following types of activity:

  • Implantable medical devices
  • Cell therapy
  • Tissue engineering
  • Research from Technology Readiness Level 3 upwards

Our work has included project management, engineering and technical support during both the research and production scale-up phases.  We have also supported the Risk Control Strategy for product first-in-man trials (utilising ISO14971 Risk Control), and the establishment of ISO13485 quality management system for the GMP manufacturing of ethical products. Lorien also has a log-established track record in research facilities in general, acting as the lead designer, project manager and construction management for many research and laboratory builds.  The following laboratory types, with the associated changing facilities and utilities, have been handled by Lorien:

  • Chemistry R&D
  • Biology R&D
  • Radiation research laboratory
  • Electro-magnetic research laboratory
  • High-care human pathogen research laboratory
  • Pain laboratory
  • Phlebotomy procedure room
  • QC sampling test laboratory
  • Microbiology laboratory
  • Production laboratories and procedure suites
  • Aquatic species research
  • Perfumes test laboratory
  • High-care dispensing laboratory
  • Cell culture laboratory (Grade B)

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